Maryanne Mathias and Molly Keogh developed Osei-Duro to create socially responsible and sustainable clothing that encourages international/intercultural cooperation. The designers integrate West African textiles with contemporary Western clothing design.

Mathias and Keogh work directly with the West African garment workers who produce the clothing. This allows the designers to pay their employees an equitable wage and observe high quality standards. Unlike most factory systems that protect their designs and fragment the construction process into specialized tasks, Osei-Duro encourages the seamstresses to produce for their own gain outside of the orders Mathias and Keogh place. The seamstress negotiate prices with Osei-Duro based on their needs, the time the piece takes to complete, and relative to previous work done.

Osei-Duro’s designs use mainly natural (non-petroleum-based) materials such as hand-spun cotton and the garments are often hand-dyed. Osei-Duro seeks out fabrics that have been grown, spun, woven, and printed in West Africa, making the material a completely West African product.